Composite neuroendocrine tumor and adenocarcinoma of the rectum

Composite neuroendocrine tumor and adenocarcinoma of the rectum

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Abstract Background Although adenocarcinomas showing neuroendocrine differentiation or those mixed with high-grade neuroendocrine carcinoma (NEC) are sometimes encountered, composite tumors comprising neuroendocrine tumor (NET) Grade 1 and adenocarcinoma are exceedingly rare.Case presentation A 64-year-old male presented after testing Medium Weight positive for fecal occult blood at a medical check-up.A biopsy demonstrated the presence of a NET and endoscopic submucosal dissection was undertaken.Histologic examination revealed that a well Beard differentiated tubular adenocarcinoma was present in addition to the NET.Furthermore, histological transition between the two tumors was evident.

Accordingly, this case was considered to be a composite tumor comprising NET and adenocarcinoma.Conclusion Composite tumors consisting of NET Grade 1 and adenocarcinoma are exceedingly rare, and only a few examples have been reported hitherto.